MLPH Polyclonal Antibody

Background:
This gene encodes a member of the exophilin subfamily of Rab effector proteins. The protein forms a ternary complex with the small Ras-related GTPase Rab27A in its GTP-bound form and the motor protein myosin Va. A similar protein complex in mouse functions to tether pigment-producing organelles called melanosomes to the actin cytoskeleton in melanocytes, and is required for visible pigmentation in the hair and skin. A mutation in this gene results in Griscelli syndrome type 3, which is characterized by a silver-gray hair color and abnormal pigment distribution in the hair shaft. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Research Area: Neuroscience, Signal Transduction

Synonyms:
MLPH, SLAC2-A

Immunogen: Recombinant fusion protein of human MLPH (NP_077006.1).

Swissprot: Q9BV36
Gene ID: 79083

Calculated MW: 50 kDa/52 kDa/60 kDa/62 kDa/65 kDa
Observed MW: 75 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: "WB 1:500-1:2000 IF 1:50-1:200"

Storage:
Store at -20°C. Avoid freeze / thaw cycles.