MMP-10 polyclonal, anti-human, mouse, rat
€388.00
In stock
SKU
BS7167
Background:
Proteins of the matrix metalloproteinase (MMP) family are zinc containing proteolytic enzymes involved in the breakdown of the extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling. They also play an important role in apoptosis, tumor cell growth, invasion, metastasis, as well as in angiogenesis and wound healing. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. Most of the MMP's contain a common domain structure, which include a signal sequence, a propeptide, a catalytic domain and a hemopexin-like (Hpx) domain. MMP10 degrades proteoglycans, gelatins of type I, III, IV, and V; weakly collagens III, IV, and V. and fibronectin. It activates procollagenase.
Alternative Name:
Stromelysin-2, SL-2, Matrix metalloproteinase-10, MMP-10, Transin-2, MMP10, STMY2
Application Dilution: WB: 1:500~1:2000, IHC: 1:50~1:200
Specificity: MMP-10 polyclonal antibody detects endogenous levels of MMP-10 protein.
Immunogen:
Recombinant full length Human MMP-10.
MW: ~ 54 kDa
Swis Prot.: P09238
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Proteins of the matrix metalloproteinase (MMP) family are zinc containing proteolytic enzymes involved in the breakdown of the extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling. They also play an important role in apoptosis, tumor cell growth, invasion, metastasis, as well as in angiogenesis and wound healing. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. Most of the MMP's contain a common domain structure, which include a signal sequence, a propeptide, a catalytic domain and a hemopexin-like (Hpx) domain. MMP10 degrades proteoglycans, gelatins of type I, III, IV, and V; weakly collagens III, IV, and V. and fibronectin. It activates procollagenase.
Alternative Name:
Stromelysin-2, SL-2, Matrix metalloproteinase-10, MMP-10, Transin-2, MMP10, STMY2
Application Dilution: WB: 1:500~1:2000, IHC: 1:50~1:200
Specificity: MMP-10 polyclonal antibody detects endogenous levels of MMP-10 protein.
Immunogen:
Recombinant full length Human MMP-10.
MW: ~ 54 kDa
Swis Prot.: P09238
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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