MMP-13 polyclonal, anti-human, mouse, rat, rabbit, pig, bovine, monkey, horse, dog, sheep

Protein Family: Enzymes, Peptidases

Pathway and Disease: Signaling Molecules and Interaction

Description:
Collagenase 3 (MMP-13) is a protein of the matrix metalloproteinase (MMP) family. MMP-13 is involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The protein encoded by this gene cleaves type II collagen more efficiently than types I and III. It may be involved in articular cartilage turnover and cartilage pathophysiology associated with osteoarthritis. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3

Alternate Names: MMP-13, Matrix metalloproteinase-13, Collagenase 3, MMP13

Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500

Accession No.: P45452

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the center region of human MMP-13.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 25% glycerol, 1 mg/ml BSA with 0.09% sodium azide. Antibody was purified by Protein-A affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.