MMP-14 polyclonal, anti-human, mouse, rat

Protein Family: Enzymes, Peptidases

Pathway and Disease: Signaling Molecules and Interaction

Description:
Matrix metalloproteinase-14 (MMP-14) specifically activates progelatinase A on the surface of tumor cells, thereby triggering metastasis. MMP-14 activates progelatinase A by cleavage of the propeptide at 37-Asn-|-Leu-38. Other bonds hydrolyzed include 35-Gly-|-Ile-36 in the propeptide of collagenase 3, and 341-Asn-|-Phe-342, 441-Asp-|-Leu-442 and 354-Gln-|-Thr-355 in the aggrecan interglobular domain.

Alternate Names: MMP-14, Matrix metalloproteinase-14, Membrane-type matrix metalloproteinase 1, MT-MMP1, MTMMP1, Membrane-type-1 matrix metalloproteinase, MT1-MMP, MT1MMP, MMP-X1, MMP14

Application Notes: E: 1:1,000-1:10,000; WB: 1:100-1:500; IHC: 1:100-1:500

Accession No.: P50281

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the center region of human MMP-14.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 ,0.2% BSA with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.