MMP-2 (clone 3A8-C1-E8), anti-transfected rat human

Background:
This gene is a member of the matrix metalloproteinase (MMP) gene family, that are zinc-dependent enzymes capable of cleaving components of the extracellular matrix and molecules involved in signal transduction. The protein encoded by this gene is a gelatinase A, type IV collagenase, that contains three fibronectin type II repeats in its catalytic site that allow binding of denatured type IV and V collagen and elastin. Unlike most MMP family members, activation of this protein can occur on the cell membrane. This enzyme can be activated extracellularly by proteases, or, intracellulary by its S-glutathiolation with no requirement for proteolytical removal of the pro-domain. This protein is thought to be involved in multiple pathways including roles in the nervous system, endometrial menstrual breakdown, regulation of vascularization, and metastasis. Mutations in this gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms.

Synonyms: CLG4, CLG4A, MMP-2, MMP-II, MONA, TBE-1

Cellular Location: Cytoplasm Membrane Mitochondrion Nucleus Secreted extracellular matrix extracellular space

Immunogen:
Purified recombinant human MMP-2 protein expressed in E.coli.

Gene Symbol: MMP-2

Gene ID: 4313

Swiss prot: P08253

Calculated MW: 72kDa

Recommended dilution:
WB 1:1000

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.