MMP-2 polyclonal, anti-human, mouse, rat, sheep, pig, bovine
€422.00
In stock
SKU
250752
Catalog Nr.: 250752
Size: 0.1 mg
Isotype: Rabbit Ig
Applications: E, WB, IHC
Datasheet
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Size: 0.1 mg
Isotype: Rabbit Ig
Applications: E, WB, IHC
Datasheet
Request Information
Protein Family: CAM Ligands, Enzymes, Peptidases
Pathway and Disease: Cancers, Endocrine System, Immune System
Description:
Matrix metalloproteinase protein family (MMP) is involved in the breakdown of extracellular matrix in normal physiological processes such as embryonic development, reproduction, and tissue remodeling, as well as in diseases such as arthritis and metastasis. Most MMPs are secreted as inactive precursors which are activated upon cleavage by extracellular proteinases. MMP-2 is an enzyme that degrades gelatin type I and collagen types IV, V, VII and X, and KiSS1. MMP-2 is also a ligand for the integrin alpha-V/beta-3. Defects in MMP-2 are the cause of multicentric osteolysis nodulosis and arthropathy (MONA), and Winchester syndrome, both characterized by excessive destruction and resorption of bones.
Alternate Names: 72 kDa type IV collagenase, 72 kDa gelatinase, Matrix metalloproteinase-2, MMP-2, Gelatinase A, TBE-1, MMP2, CLG4A
Application Notes: E: 1:500-1:1,000; WB: 1:200-1:500; IHC: 1:200-1:500
Accession No.: P08253
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human MMP-2.
Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Product Citations:
[1] Zhu J. et al. 2015. Mol Med Rep. 11(6): 4501-7. PMID# 25634369.
[2] Oliveira O et al. 2013. Int J Exp Pathol. doi: 10.1111/iep.12033. PMID# 23786352.
[3] Riau A et al. PLoS One. 2011. 6(2): e14687.PMID# 21359202.
[4] Li X et al. 2011. Medical Oncology. 29(2):714-720. PMID# 214319960.
[5] Seet L et al. PLoS One. 2010. 5(2): e9415. PMID# 20195533.
Pathway and Disease: Cancers, Endocrine System, Immune System
Description:
Matrix metalloproteinase protein family (MMP) is involved in the breakdown of extracellular matrix in normal physiological processes such as embryonic development, reproduction, and tissue remodeling, as well as in diseases such as arthritis and metastasis. Most MMPs are secreted as inactive precursors which are activated upon cleavage by extracellular proteinases. MMP-2 is an enzyme that degrades gelatin type I and collagen types IV, V, VII and X, and KiSS1. MMP-2 is also a ligand for the integrin alpha-V/beta-3. Defects in MMP-2 are the cause of multicentric osteolysis nodulosis and arthropathy (MONA), and Winchester syndrome, both characterized by excessive destruction and resorption of bones.
Alternate Names: 72 kDa type IV collagenase, 72 kDa gelatinase, Matrix metalloproteinase-2, MMP-2, Gelatinase A, TBE-1, MMP2, CLG4A
Application Notes: E: 1:500-1:1,000; WB: 1:200-1:500; IHC: 1:200-1:500
Accession No.: P08253
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human MMP-2.
Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Product Citations:
[1] Zhu J. et al. 2015. Mol Med Rep. 11(6): 4501-7. PMID# 25634369.
[2] Oliveira O et al. 2013. Int J Exp Pathol. doi: 10.1111/iep.12033. PMID# 23786352.
[3] Riau A et al. PLoS One. 2011. 6(2): e14687.PMID# 21359202.
[4] Li X et al. 2011. Medical Oncology. 29(2):714-720. PMID# 214319960.
[5] Seet L et al. PLoS One. 2010. 5(2): e9415. PMID# 20195533.
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