MMP-9 polyclonal, anti-human, rat, guinea pig

Protein Family: Enzymes, Peptidases

Pathway and Disease: Cancers, Immune System

Description:
Matrix metalloproteinase protein family (MMP) is involved in the breakdown of extracellular matrix in normal physiological processes such as embryonic development, reproduction, and tissue remodeling, as well as in diseases such as arthritis and metastasis. Most MMPs are secreted as inactive precursors which are activated upon cleavage by extracellular proteinases. MMP-9 is an enzyme that degrades gelatin types I and V, and collagen types IV and V, and KiSS1. MMP-9 has an essential role in local proteolysis of the extracellular matrix, in leukocyte migration and possibly in bone osteoclastic resorption. MMP-9 exists as a monomer, disulfide-linked homodimer, and as a heterodimer with a 25-kDa protein. Macrophages and transformed cell lines only produce the monomeric form. Processing of the precursor yields different active forms of 64, 67 and 82 kDa. Defects in MMP-9 may be a cause of susceptibility to lumbar disk herniation (LDH), a predominant cause of low-back pain. MMP-9 could be a disease status marker in arthritis patients.

Alternate Names: Matrix metalloproteinase-9, MMP-9, 92 kDa type IV collagenase, 92 kDa gelatinase, Gelatinase B, GELB

Application Notes: E: 1:500-1:1,000; WB: 1:200-1:500; IHC: 1:200-1:500

Accession No.: P14780

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human MMP-9.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 25% glycerol, 1 mg/ml BSA with 0.09% sodium azide. Antibody was purified by Protein-A affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.

Product Citations:
[1] Gallo RL et al. 2016. US Patent 20,160,030,386.
[2] Agabiti-Rosei C et al. 2014. J. Hypertens. 32(6): 1264-74. PMID 24751595.
[3] Ambalavanan N et al. 2013. Amer J Physiol-Lung Cell Mol Physiol. 304(3): L152-L161. PMID 23220372.
[4] Li X et al. 2011. Med Oncol. 29(2): 714-20. PMID 21431960.
[5] Pina Y et al. 2010. Inv Opthalmol Vis Sci. 51: 2671-7. PMID 20053982.
[6] Bajenaru M et al. 2010. Inv Ophthalmol Vis Sci. 51: 2860-4. PMID 20107171.