MMP13 Antibody (C-term) Blocking Peptide
€363.00
In stock
SKU
AC-BP6197a
Background:
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development,reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. MMP13 cleaves type II collagen more efficiently than types I and III. It may be involved in articular cartilage turnover and cartilage pathophysiology associated with osteoarthritis. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.
Other Names:
Collagenase 3, 3424-, Matrix metalloproteinase-13, MMP-13, MMP13
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP6197a was selected from the C-term region of human MMP13 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: MMP13
Gene ID: 4322
Primary Accession: P45452
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development,reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. MMP13 cleaves type II collagen more efficiently than types I and III. It may be involved in articular cartilage turnover and cartilage pathophysiology associated with osteoarthritis. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.
Other Names:
Collagenase 3, 3424-, Matrix metalloproteinase-13, MMP-13, MMP13
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP6197a was selected from the C-term region of human MMP13 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: MMP13
Gene ID: 4322
Primary Accession: P45452
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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