MMP2 [clone CA-4001], anti-human

Description: MMPs are proteolytic enzymes capable of degrading connective tissue components. They have a common mode of activation, a conserved amino acid sequence in the putative metal binding-active site region, and are inhibited by specific tissue inhibitors of metalloproteinases (TIMPs). MMPa and TIMPs play a significant role in regulating angiogenesis. MMP-2 is synthesized as a 631 amino acid proenzyme which is activated by cleavage of the first 80 amino acids. This antibody reacts with both latent and active MMP-2.Localization: cytoplasmDilution: 25-50Positive Control: placenta, bladder, breast, ovarian caHIER: citrate pH6.0 or EDTA pH8.0Status: RUO