MMP2 polyclonal, anti-human, mouse, rat

Quantity: 100 µg

Background:
Matrix metalloproteinase-2(MMP2) is a Type IV collagenase, 72-kD, which is also known as gelatinase and is a member of a group of secreted zinc metalloproteases. The MMP2 gene is 17 kb long with 13 exons varying in size from 110 to 901 bp and 12 introns ranging from 175 to 4,350 bp, located within a region of human chromosome 16q13. In addition, the extra exons encode the amino acids of the fibronectin-like domain which has so far been found in only the 72- and 92-kDa type IV collagenase. MMP2, which has a critical role in the binding of progelatinase A and TIMP4 via the C-terminal hemopexin-like domain(C domain), is functionally associated on the surface of angiogenic blood vessels. NOT only is a likely effector of endometrial menstrual breakdown, MMP2 is also effector and regulator of the inflammatory response. Moreover, MMP2 could be helpful in diagnosing Takayasu arteritis.

Description:
Rabbit IgG polyclonal antibody for 72 kDa type IV collagenase (MMP2) detection. Tested with WB, IHC-P, IHC-F in Human, Mouse, Rat.

Synonyms:
72 kDa gelatinase antibody, 72kD type IV collagenase antibody, CLG 4 antibody, CLG 4A antibody, CLG4 antibody, CLG4A antibody, Collagenase Type 4 alpha antibody, Collagenase type IV A antibody, Gelatinase A antibody, Gelatinase alpha antibody, Gelatinase neutrophil antibody, Matrix metallopeptidase 2 gelatinase A 72kDa gelatinase 72kDa type IV collagenase antibody, Matrix metalloproteinase 2(gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) antibody, Matrix Metalloproteinase 2 antibody, Matrix metalloproteinase II antibody, Matrix metalloproteinase-2 antibody, MMP 2 antibody, MMP II antibody, MMP-2 antibody, MMP2 antibody, MMP2_HUMAN antibody, MONA antibody, Neutrophil gelatinase antibody, PEX antibody, TBE 1 antibody, TBE-1 antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence at the N-terminus of human MMP2(138-153aa ETVDDAFARAFQVWSD), different from the related rat and mouse sequences by two amino acids.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human, mouse, rat

Applications: WB, IHC-P, IHC-F

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.