MMP2 polyclonal (Center), anti-human
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In stock
SKU
AC-AP13693c
Catalog Number: AC-AP13693c
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB33605
Applications: WB
Datasheet
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Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB33605
Applications: WB
Datasheet
Request Information
Background:
Proteins of the matrix metalloproteinase (MMP) family areinvolved in the breakdown of extracellular matrix in normalphysiological processes, such as embryonic development,reproduction, and tissue remodeling, as well as in diseaseprocesses, such as arthritis and metastasis. Most MMP's aresecreted as inactive proproteins which are activated when cleavedby extracellular proteinases. This gene encodes an enzyme whichdegrades type IV collagen, the major structural component ofbasement membranes. The enzyme plays a role in endometrialmenstrual breakdown, regulation of vascularization and theinflammatory response. Mutations in this gene have been associatedwith Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO)syndrome. Two transcript variants encoding different isoforms havebeen found for this gene.
Other Names:
72 kDa type IV collagenase, 72 kDa gelatinase, Gelatinase A, Matrix metalloproteinase-2, MMP-2, TBE-1, PEX, MMP2, CLG4A
Target/Specificity:
This MMP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 303-331 amino acids from the Central region of human MMP2.
Antigen Region:
303-331
Antigen Type: Synthetic Peptide
Gene Name: MMP2
Gene ID: 4313
Primary Accession: P08253
NCBI Accession: NP_001121363.1;NP_004521.1
Other Accession: P33436; P50757; P33434; Q90611; NP_004521.1; NP_001121363.1
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Proteins of the matrix metalloproteinase (MMP) family areinvolved in the breakdown of extracellular matrix in normalphysiological processes, such as embryonic development,reproduction, and tissue remodeling, as well as in diseaseprocesses, such as arthritis and metastasis. Most MMP's aresecreted as inactive proproteins which are activated when cleavedby extracellular proteinases. This gene encodes an enzyme whichdegrades type IV collagen, the major structural component ofbasement membranes. The enzyme plays a role in endometrialmenstrual breakdown, regulation of vascularization and theinflammatory response. Mutations in this gene have been associatedwith Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO)syndrome. Two transcript variants encoding different isoforms havebeen found for this gene.
Other Names:
72 kDa type IV collagenase, 72 kDa gelatinase, Gelatinase A, Matrix metalloproteinase-2, MMP-2, TBE-1, PEX, MMP2, CLG4A
Target/Specificity:
This MMP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 303-331 amino acids from the Central region of human MMP2.
Antigen Region:
303-331
Antigen Type: Synthetic Peptide
Gene Name: MMP2
Gene ID: 4313
Primary Accession: P08253
NCBI Accession: NP_001121363.1;NP_004521.1
Other Accession: P33436; P50757; P33434; Q90611; NP_004521.1; NP_001121363.1
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
| Is Featured? | No |
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