MMP23 Antibody (N-term) Blocking Peptide
€363.00
In stock
SKU
AC-BP6204a
Background:
Matrix Metalloproteases (MMPs) are zinc-dependent endopeptidases that break down the extracellular matrix, and thus play important roles in many physiological processes including embryonic development, wound healing, reproduction, tissue remodeling, arthritis, cancer and cardiovascular disease. Although most MMPs are secreted, the membrane-type MMPs (MT-MMPs) are anchored to the cell membrane by a transmembrane and intracytoplasmic domain. MMP activities are regulated at several levels, including cleavage of proenzyme forms and suppression via tissue inhibitors of metalloproteinases (TIMPs). Matrix Metalloproteinase 23, first identified in tumor cells, features a number of unqie properties among the MMPs: 1) cysteine array unique among the MMPs, 2) sublocalized expression of MMP23 to reproductive organs, 3) a furin cleavage site, 4) and is the sole MMP mapped to chromosome 1.
Other Names:
Matrix metalloproteinase-23, MMP-23, 3424-, Femalysin, MIFR-1, Matrix metalloproteinase-21, MMP-21, Matrix metalloproteinase-22, MMP-22, Matrix metalloproteinase-23, soluble form, MMP23A, MMP21
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP6204a was selected from the N-term region of human MMP23 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: MMP23B
Gene ID: 8510
Primary Accession: O75900
Other Accession: NP_008914
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Matrix Metalloproteases (MMPs) are zinc-dependent endopeptidases that break down the extracellular matrix, and thus play important roles in many physiological processes including embryonic development, wound healing, reproduction, tissue remodeling, arthritis, cancer and cardiovascular disease. Although most MMPs are secreted, the membrane-type MMPs (MT-MMPs) are anchored to the cell membrane by a transmembrane and intracytoplasmic domain. MMP activities are regulated at several levels, including cleavage of proenzyme forms and suppression via tissue inhibitors of metalloproteinases (TIMPs). Matrix Metalloproteinase 23, first identified in tumor cells, features a number of unqie properties among the MMPs: 1) cysteine array unique among the MMPs, 2) sublocalized expression of MMP23 to reproductive organs, 3) a furin cleavage site, 4) and is the sole MMP mapped to chromosome 1.
Other Names:
Matrix metalloproteinase-23, MMP-23, 3424-, Femalysin, MIFR-1, Matrix metalloproteinase-21, MMP-21, Matrix metalloproteinase-22, MMP-22, Matrix metalloproteinase-23, soluble form, MMP23A, MMP21
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP6204a was selected from the N-term region of human MMP23 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: MMP23B
Gene ID: 8510
Primary Accession: O75900
Other Accession: NP_008914
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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