MMP24 polyclonal, anti-human, mouse, rat

Quantity: 100 µg

Background:
Matrix metalloproteinase-24, also known as MT5MMP or MMP25, is an enzyme that in humans is encoded by the MMP24 gene. Proteins of the matrix metalloproteinase(MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP(MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 by cleavage. The gene has previously been referred to as MMP25 but has been renamed MMP24. This gene may be a proteoglycanase involved in degradation of proteoglycans, such as dermatan sulfate and chondroitin sulfate proteoglycans.

Description:
Rabbit IgG polyclonal antibody for Matrix metalloproteinase-24 (MMP24) detection. Tested with WB in Human, Mouse, Rat.

Synonyms:
Matrix metallopeptidase 24(membrane inserted) antibody, Matrix metallopeptidase 24 antibody, Membrane type 5 matrix metalloproteinase antibody, Membrane type matrix metalloproteinase 5 antibody, Membrane-type matrix metalloproteinase 5 antibody, Membrane-type-5 matrix metalloproteinase antibody, MMP 24 antibody, MMP 25 antibody, MMP-24 antibody, Mmp24 antibody, MMP24_HUMAN antibody, MMP25 antibody, MT MMP5 antibody, MT-MMP 5 antibody, MT5 MMP antibody, MT5-MMP antibody, MT5MMP antibody, MTMMP5 antibody, Processed matrix metalloproteinase-24 antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence at the N-terminus of human MMP24(208-225aa YHEIKSDRKEADIMIFFA), identical to the related mouse and rat sequences.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human.
Predicted to work with: mouse, rat.

Applications: WB

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.