MMP25 polyclonal (C-term), anti-human, mouse
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In stock
SKU
AC-AP6206a
Catalog Number: AC-AP6206a
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB2043
Applications: WB
Datasheet
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Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB2043
Applications: WB
Datasheet
Request Information
Background:
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, MMP25 is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. In addition, it is thought that this protein is activated intracellularly by furin-like enzymes. This protein activates MMP2 by cleavage. The gene has previously been referred to as MMP20 but has been renamed matrix metalloproteinase 25 (MMP25).
Other Names:
Matrix metalloproteinase-25, MMP-25, 3424-, Leukolysin, Membrane-type matrix metalloproteinase 6, MT-MMP 6, MTMMP6, Membrane-type-6 matrix metalloproteinase, MT6-MMP, MT6MMP, MMP25, MMP20, MMPL1, MT6MMP
Target/Specificity:
This MMP25 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 470-499 amino acids from the C-terminal region of human MMP25.
Antigen Region:
470-499
Antigen Type: Synthetic Peptide
Gene Name: MMP25
Gene ID: 64386
Primary Accession: Q9NPA2
NCBI Accession: NP_071913.1
Other Accession: NP_071913
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, MMP25 is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. In addition, it is thought that this protein is activated intracellularly by furin-like enzymes. This protein activates MMP2 by cleavage. The gene has previously been referred to as MMP20 but has been renamed matrix metalloproteinase 25 (MMP25).
Other Names:
Matrix metalloproteinase-25, MMP-25, 3424-, Leukolysin, Membrane-type matrix metalloproteinase 6, MT-MMP 6, MTMMP6, Membrane-type-6 matrix metalloproteinase, MT6-MMP, MT6MMP, MMP25, MMP20, MMPL1, MT6MMP
Target/Specificity:
This MMP25 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 470-499 amino acids from the C-terminal region of human MMP25.
Antigen Region:
470-499
Antigen Type: Synthetic Peptide
Gene Name: MMP25
Gene ID: 64386
Primary Accession: Q9NPA2
NCBI Accession: NP_071913.1
Other Accession: NP_071913
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
| Is Featured? | No |
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