MMP26 Blocking Peptide (Center)

Background:
Proteins of the matrix metalloproteinase (MMP) family areinvolved in the breakdown of extracellular matrix in normalphysiological processes, such as embryonic development,reproduction, and tissue remodeling, as well as in diseaseprocesses, such as arthritis and metastasis. Most MMP's aresecreted as inactive proproteins which are activated when cleavedby extracellular proteinases. The encoded protein degrades type IVcollagen, fibronectin, fibrinogen, casein, vitronectin, alpha1-antitrypsin, alpha 2-macroglobulin, and insulin-like growthfactor-binding protein 1, and activates MMP9 by cleavage. Theprotein differs from most MMP family members in that it lacks aconserved C-terminal protein domain.

Other Names:
Matrix metalloproteinase-26, MMP-26, 3424-, Endometase, Matrilysin-2, MMP26

Target/Specificity:
The synthetic peptide sequence is selected from aa 111-125 of HUMAN MMP26

Gene Name: MMP26

Gene ID: 56547
Primary Accession: Q9NRE1
Other Accession: NP_068573.2
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.