MMP7 (Cleaved-Tyr95) Rabbit polyclonal antibody, anti-human, mouse, rat

Background:
Catalytic activity:Cleavage of 14-Ala-|-Leu-15 and 16-Tyr-|-Leu-17 in B chain of insulin. No action on collagen types I| II| IV| V. Cleaves gelatin chain alpha-2(I) > alpha-1(I).|cofactor:Binds 2 calcium ions per subunit.|cofactor:Binds 2 zinc ions per subunit.|The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion| thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.|Degrades casein| gelatins of types I| III| IV| and V| and fibronectin. Activates procollagenase.|Belongs to the peptidase M10A family.|

Research Area: Cancer, Cardiovascular, Cell biology, Signal transduction

Synonyms: MMP7 , Cleaved-Tyr95, Matrilysin, EC 3.4.24.23, Matrin, Matrix metalloproteinase-7, MMP-7, Pump-1 protease, Uterine metalloproteinase

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

Storage:
-20°C for 1 year