MMP7 polyclonal, anti-human

Quantity: 100 µg

Background:
Matrix metalloproteinase-7 (MMP-7) previously called putative metalloproteinase I (PUMP1) or matrilysin. The MMP-7 gene has been identified through studies of collagenase-related connective-tissue-degrading metalloproteinases produced by human tumors. The MMP-7 protein has 267 amino acids and is significantly shorter than stromelysin or collagenase (477 and 469 amino acids, respectively). Matrix metalloproteinases play a crucial role in tumor invasion and metastasis. MMP-7, a member of the matrix metalloproteinase family, is structurally different from the other matrix metalloproteinases by virtue of the absence of a conserved COOH-terminal protein domain. In addition, MMP-7 mRNA is regulated in a specific and distinct manner in normal and malignant tissues. MMP-7 has been shown to correlate with nodal or distant metastasis in colorectal carcinomas, however, its implication in early invasive colorectal carcinomas has not been determined. MMP-7 is also a mediator of pulmonary fibrosis and a potential therapeutic target. The standard product used in this kit is recombinant human MMP-7, consisting of 250 amino acids with the molecular mass of 28KDa. The detected MMP-7 includes zymogen and active enzyme.

Description:
Rabbit IgG polyclonal antibody for Matrilysin (MMP7) detection. Tested with WB, IHC-P, ELISA in Human.

Synonyms:
Matrilysin antibody, Matrilysin uterine antibody, Matrin antibody, Matrix Metalloproteinase 7 antibody, Matrix metalloproteinase-7 antibody, MMP 7 antibody, MMP-7 antibody, MMP7 antibody, MMP7_HUMAN antibody, MPSL1 antibody, PUMP 1 antibody, Pump 1 protease antibody, Pump-1 protease antibody, PUMP1 antibody, Uterine Matrilysin antibody, Uterine metalloproteinase antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
E.coli-derived human MMP7 recombinant protein (Position: M1-K267). Human MMP7 shares 71% amino acid (aa) sequences identity with both mouse and rat MMP7.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human

Applications: WB, IHC-P, ELISA

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.