MMP8 (Cleaved-Leu101) Rabbit polyclonal antibody, anti-human, mouse, rat

Background:
Catalytic activity:Cleavage of interstitial collagens in the triple helical domain. Unlike EC 3.4.24.7| this enzyme cleaves type III collagen more slowly than type I.|cofactor:Binds 2 zinc ions per subunit.|cofactor:Binds 3 calcium ions per subunit.|The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion| thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.|enzyme regulation:Cannot be activated without removal of the activation peptide.|Can degrade fibrillar type I| II| and III collagens.|Belongs to the peptidase M10A family.|Contains 4 hemopexin-like domains.|subcellular location:Stored in intracellular granules.|tissue specificity:Neutrophils.|

Research Area: Cancer, Cardiovascular, Cell biology, Signal transduction

Synonyms: MMP8 , Cleaved-Leu101, Neutrophil collagenase, EC 3.4.24.34, Matrix metalloproteinase-8, MMP-8, PMNL collagenase, PMNL-CL

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

Storage:
-20°C for 1 year