MMP8 Polyclonal Antibody

Background:
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is stored in secondary granules within neutrophils and is activated by autolytic cleavage. Its function is degradation of type I, II and III collagens. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.

Research Area: Cancer, Cell Biology, Cardiovascular, Signal Transduction

Synonyms:
CLG 1, CLG1, Collagenase 1, Collagenase 1 neutrophil, HNC, Matrix metallopeptidase 8 (neutrophil collagenase), Matrix metalloprotease 8, Matrix metalloproteinase-8, MMP 8, MMP-8, Mmp8, MMP8, Neutrophil collagenase, PMNL CL, PMNL collagenase, PMNL-CL, PMNLCL

Immunogen: Synthetic peptide of human MMP8

Swissprot: P22894
Gene Accession: NP_002415

Calculated MW: 53 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Concentration: 0.4 mg/mL
Dilution: WB 1:500-1:2000, IHC 1:25-1:100

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-8849/sc-8848/sc-31741/sc-50383