MMP9 Polyclonal Antibody

Background:
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades type IV and V collagens. Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow, and murine studies suggest a role in tumor-associated tissue remodeling.

Research Area: Cancer, Cell Biology, Cardiovascular, Signal Transduction

Synonyms:
MMP9, CLG4B, GELB, MANDP2, MMP-9

Immunogen: A synthetic peptide of human MMP9 (NP_004985.2).

Swissprot: P14780
Gene ID: 4318

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: IHC 1:100-1:200

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Citation(s):
https://link.springer.com/article/10.1007/s11655-018-2985-3