MMS21 polyclonal, anti-human, mouse, rat
€484.00
In stock
SKU
254284
Protein Family: Enzymes
Pathway and Disease: Signaling Molecules and Interaction
Description:
MMS21, also known as NSE2, is a SUMO ligase that in combination with the SMC5/6 complex is required for the prevention of DNA damage induced apoptosis by facilitating DNA repair in human cells. MMS21-dependent sumoylation is integral and important to the cohesion mechanism and mitotic progression; this function appears to be independent of SMC6. MMS21 mediates SUMO attachment to various proteins such as SMC6L1 and TRAX, and possibly the cohesin components RAD21 and STAG2.
Alternate Names: MMS21, E3 SUMO-protein ligase NSE2, Non-SMC element 2, NSMCE2, MMS21 homolog
Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500
Accession No.: NP_775956
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within human MMS21.
Format: Each vial contains 0.1 ml IgG in PBS pH 7.4 with 0.02% sodium azide. Antibody was purified by immunogen affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Pathway and Disease: Signaling Molecules and Interaction
Description:
MMS21, also known as NSE2, is a SUMO ligase that in combination with the SMC5/6 complex is required for the prevention of DNA damage induced apoptosis by facilitating DNA repair in human cells. MMS21-dependent sumoylation is integral and important to the cohesion mechanism and mitotic progression; this function appears to be independent of SMC6. MMS21 mediates SUMO attachment to various proteins such as SMC6L1 and TRAX, and possibly the cohesin components RAD21 and STAG2.
Alternate Names: MMS21, E3 SUMO-protein ligase NSE2, Non-SMC element 2, NSMCE2, MMS21 homolog
Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500
Accession No.: NP_775956
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within human MMS21.
Format: Each vial contains 0.1 ml IgG in PBS pH 7.4 with 0.02% sodium azide. Antibody was purified by immunogen affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
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