Mob1A/B (D127) polyclonal, anti-human, mouse, rat
€305.00
In stock
SKU
BS2322
Catalog Number: BS2322
Size: 100 µl
Other Size: 50 µl
Isotype: rabbit IgG
Applications: WB
Questions? Contact us!
Size: 100 µl
Other Size: 50 µl
Isotype: rabbit IgG
Applications: WB
Questions? Contact us!
Background:
MOB1 was first identified in yeast as a protein that binds to Mps with essential roles in the completion of mitosis and the maintenance of ploidy. Its Drosophila and mammalian homologs, Mats and MOB1, respectively, are involved in the Hippo signaling tumor suppressor pathway, which plays a critical role in organ size regulation and which has been implicated in cancer development. There are two MOB1 proteins in humans, MOB1α and MOB1β, that are encoded by two different genes but which have greater than 95% amino acid sequence identity. Both forms bind to members of the nuclear Dbf2-related (NDR) kinases, such as LATS1/2 and NDR1/2, thereby stimulating kinase activity. This binding is promoted by the phosphorylation of MOB1 at several threonine residues by MST1 and/or MST2.
Alternative Name:
MOB kinase activator 1B, Mob1 homolog 1A, Mob1A, Mob1B, Mps one binder kinase activator-like 1A, MOB1B, MOB4A, MOBKL1A
Application Dilution:
WB: 1:500~1:1000
Specificity: Mob1A/B (D127) polyclonal antibody detects endogenous levels of Mob1A/B protein.
Immunogen:
Synthetic peptide, corresponding to amino acids 97-157 of Human Mob1A/B.
MW: ~ 25 kDa
Swiss-Prot: Q7L9L4
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
MOB1 was first identified in yeast as a protein that binds to Mps with essential roles in the completion of mitosis and the maintenance of ploidy. Its Drosophila and mammalian homologs, Mats and MOB1, respectively, are involved in the Hippo signaling tumor suppressor pathway, which plays a critical role in organ size regulation and which has been implicated in cancer development. There are two MOB1 proteins in humans, MOB1α and MOB1β, that are encoded by two different genes but which have greater than 95% amino acid sequence identity. Both forms bind to members of the nuclear Dbf2-related (NDR) kinases, such as LATS1/2 and NDR1/2, thereby stimulating kinase activity. This binding is promoted by the phosphorylation of MOB1 at several threonine residues by MST1 and/or MST2.
Alternative Name:
MOB kinase activator 1B, Mob1 homolog 1A, Mob1A, Mob1B, Mps one binder kinase activator-like 1A, MOB1B, MOB4A, MOBKL1A
Application Dilution:
WB: 1:500~1:1000
Specificity: Mob1A/B (D127) polyclonal antibody detects endogenous levels of Mob1A/B protein.
Immunogen:
Synthetic peptide, corresponding to amino acids 97-157 of Human Mob1A/B.
MW: ~ 25 kDa
Swiss-Prot: Q7L9L4
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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