MOB1B Polyclonal Antibody

Background:
The protein encoded by this gene is similar to the yeast Mob1 protein. Yeast Mob1 binds Mps1p, a protein kinase essential for spindle pole body duplication and mitotic checkpoint regulation. Three transcript variants encoding different isoforms have been found for this gene.Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ.

Research Area: Signal Transduction

Synonyms:
MATS 2, MATS2, MGC33910, Mob 1A, Mob 1B, MOB 4A, MOB kinase activator 1B, Mob1 homolog 1A, MOB1 Mps One Binder homolog B, MOB1 Mps one binder kinase activator like 1A, Mob1A, Mob1B, MOBKL 1A, MOBKL1A, MOL1A, Mps one binder kinase activator like 1A, Mps one binder kinase activator-like 1A, Protein Mob4A

Immunogen: Full length fusion protein

Swissprot: Q7L9L4
Gene Accession: BC038112

Calculated MW: 25 kDa
Observed MW: Refer to figures

Purification Method: Antigen affinity purification

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Concentration: 0.8 mg/mL
Dilution: WB 1:500-1:2000, IHC 1:25-1:100, ELISA 1:5000-1:10000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.