MOBKL1B polyclonal (N-term), anti-human
€0.00
In stock
SKU
AC-AP12884a
Catalog Number: AC-AP12884a
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB19209
Applications: FC, WB
Datasheet
Request Information
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB19209
Applications: FC, WB
Datasheet
Request Information
Background:
Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38 and STK38L.
Other Names:
MOB kinase activator 1A, Mob1 alpha, Mob1A, Mob1 homolog 1B, Mps one binder kinase activator-like 1B, MOB1A, C2orf6, MOB4B, MOBK1B, MOBKL1B
Target/Specificity:
This MOBKL1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 5-33 amino acids from the N-terminal region of human MOBKL1B.
Antigen Region:
5-33
Antigen Type: Synthetic Peptide
Gene Name: MOB1A (HGNC:16015)
Gene ID: 55233
Primary Accession: Q9H8S9
NCBI Accession: NP_060691.2
Other Accession: Q8BPB0; Q7L9L4; Q3T1J9; Q921Y0; NP_060691.2
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38 and STK38L.
Other Names:
MOB kinase activator 1A, Mob1 alpha, Mob1A, Mob1 homolog 1B, Mps one binder kinase activator-like 1B, MOB1A, C2orf6, MOB4B, MOBK1B, MOBKL1B
Target/Specificity:
This MOBKL1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 5-33 amino acids from the N-terminal region of human MOBKL1B.
Antigen Region:
5-33
Antigen Type: Synthetic Peptide
Gene Name: MOB1A (HGNC:16015)
Gene ID: 55233
Primary Accession: Q9H8S9
NCBI Accession: NP_060691.2
Other Accession: Q8BPB0; Q7L9L4; Q3T1J9; Q921Y0; NP_060691.2
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
| Is Featured? | No |
|---|
Write Your Own Review