Mouse CCND2 polyclonal (C-term T279/T280), anti-mouse
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In stock
SKU
AC-AP20417b
Catalog Number: AC-AP20417b
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB43028
Applications: WB
Datasheet
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Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB43028
Applications: WB
Datasheet
Request Information
Background:
Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D2/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex (By similarity).
Other Names:
G1/S-specific cyclin-D2, Ccnd2, Cyl-2
Target/Specificity:
This Mouse CCND2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 258-285 amino acids from the C-terminal region of mouse CCND2.
Antigen Region:
258-285
Antigen Type: Synthetic Peptide
Gene Name: Ccnd2 {ECO:0000312|MGI:MGI:88314}
Gene ID: 12444
Primary Accession: P30280
NCBI Accession: NP_033959.1
Other Accession: Q04827
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D2/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex (By similarity).
Other Names:
G1/S-specific cyclin-D2, Ccnd2, Cyl-2
Target/Specificity:
This Mouse CCND2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 258-285 amino acids from the C-terminal region of mouse CCND2.
Antigen Region:
258-285
Antigen Type: Synthetic Peptide
Gene Name: Ccnd2 {ECO:0000312|MGI:MGI:88314}
Gene ID: 12444
Primary Accession: P30280
NCBI Accession: NP_033959.1
Other Accession: Q04827
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
| Is Featured? | No |
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