Mouse Cdk7 Antibody (N-term) Blocking Peptide
€363.00
In stock
SKU
AC-BP14782a
Background:
Cyclin-dependent kinases (CDKs) are activated by the binding to a cyclin and mediate the progression through the cell cycle. Each different complex controls a specific transition between two subsequent phases in the cell cycle. CDK7 is the catalytic subunit of the CDK-activating kinase (CAK) complex, a serine-threonine kinase. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminus domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle.
Other Names:
Cyclin-dependent kinase 7, 39 kDa protein kinase, P39 Mo15, CDK-activating kinase, CR4 protein kinase, CRK4, Cell division protein kinase 7, Protein-tyrosine kinase MPK-7, TFIIH basal transcription factor complex kinase subunit, Cdk7, Cak, Cdkn7, Crk4, Mo15, Mpk-7
Gene Name: Cdk7
Gene ID: 12572
Primary Accession: Q03147
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Cyclin-dependent kinases (CDKs) are activated by the binding to a cyclin and mediate the progression through the cell cycle. Each different complex controls a specific transition between two subsequent phases in the cell cycle. CDK7 is the catalytic subunit of the CDK-activating kinase (CAK) complex, a serine-threonine kinase. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminus domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle.
Other Names:
Cyclin-dependent kinase 7, 39 kDa protein kinase, P39 Mo15, CDK-activating kinase, CR4 protein kinase, CRK4, Cell division protein kinase 7, Protein-tyrosine kinase MPK-7, TFIIH basal transcription factor complex kinase subunit, Cdk7, Cak, Cdkn7, Crk4, Mo15, Mpk-7
Gene Name: Cdk7
Gene ID: 12572
Primary Accession: Q03147
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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