Mouse Chek1 polyclonal (Center), anti-mouse
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In stock
SKU
AC-AP14611c
Catalog Number: AC-AP14611c
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB34741
Applications: WB
Datasheet
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Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB34741
Applications: WB
Datasheet
Request Information
Background:
Required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. May also negatively regulate cell cycle progression during unperturbed cell cycles. Recognizes the substrate consensus sequence [R-X-X-S/T]. Binds to and phosphorylates CDC25A, CDC25B and CDC25C. Phosphorylation of CDC25A at 'Ser-171' and 'Thr-497' and phosphorylation of CDC25C creates binding sites for 14-3-3 proteins which inhibit CDC25A and CDC25C. Phosphorylation of CDC25A at 'Ser-74', 'Ser-122', 'Ser-171', 'Ser-271' and 'Ser-284' promotes proteolysis of CDC25A. Inhibition of CDC25 activity leads to increased inhibitory tyrosine phosphorylation of CDK-cyclin complexes and blocks cell cycle progression. Binds to and phosphorylates RAD51 at 'Thr-309', which may enhance the association of RAD51 with chromatin and promote DNA repair by homologous recombination. Binds to and phosphorylates TLK1 at 'Ser-743', which prevents the TLK1-dependent phosphorylation of the chromatin assembly factor ASF1A. This may affect chromatin assembly during S phase or DNA repair. May also phosphorylate multiple sites within the C-terminus of TP53, which promotes activation of TP53 by acetylation and enhances suppression of cellular proliferation (By similarity). Essential for early embryogenesis.
Other Names:
Serine/threonine-protein kinase Chk1, CHK1 checkpoint homolog, Checkpoint kinase-1, Chek1, Chk1
Target/Specificity:
This Mouse Chek1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 252-279 amino acids from the Central region of mouse Chek1.
Antigen Region:
252-279
Antigen Type: Synthetic Peptide
Gene Name: Chek1
Gene ID: 12649
Primary Accession: O35280
NCBI Accession: NP_031717.2
Other Accession: Q91ZN7; NP_031717.2
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. May also negatively regulate cell cycle progression during unperturbed cell cycles. Recognizes the substrate consensus sequence [R-X-X-S/T]. Binds to and phosphorylates CDC25A, CDC25B and CDC25C. Phosphorylation of CDC25A at 'Ser-171' and 'Thr-497' and phosphorylation of CDC25C creates binding sites for 14-3-3 proteins which inhibit CDC25A and CDC25C. Phosphorylation of CDC25A at 'Ser-74', 'Ser-122', 'Ser-171', 'Ser-271' and 'Ser-284' promotes proteolysis of CDC25A. Inhibition of CDC25 activity leads to increased inhibitory tyrosine phosphorylation of CDK-cyclin complexes and blocks cell cycle progression. Binds to and phosphorylates RAD51 at 'Thr-309', which may enhance the association of RAD51 with chromatin and promote DNA repair by homologous recombination. Binds to and phosphorylates TLK1 at 'Ser-743', which prevents the TLK1-dependent phosphorylation of the chromatin assembly factor ASF1A. This may affect chromatin assembly during S phase or DNA repair. May also phosphorylate multiple sites within the C-terminus of TP53, which promotes activation of TP53 by acetylation and enhances suppression of cellular proliferation (By similarity). Essential for early embryogenesis.
Other Names:
Serine/threonine-protein kinase Chk1, CHK1 checkpoint homolog, Checkpoint kinase-1, Chek1, Chk1
Target/Specificity:
This Mouse Chek1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 252-279 amino acids from the Central region of mouse Chek1.
Antigen Region:
252-279
Antigen Type: Synthetic Peptide
Gene Name: Chek1
Gene ID: 12649
Primary Accession: O35280
NCBI Accession: NP_031717.2
Other Accession: Q91ZN7; NP_031717.2
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
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