Mouse Dclk1 Antibody (N-term) Blocking Peptide
€363.00
In stock
SKU
AC-BP14964a
Background:
This gene encodes a member of the protein kinasesuperfamily and the doublecortin family. The protein encoded bythis gene contains two N-terminal doublecortin domains, which bindmicrotubules and regulate microtubule polymerization, a C-terminalserine/threonine protein kinase domain, which shows substantialhomology to Ca2+/calmodulin-dependent protein kinase, and aserine/proline-rich domain in between the doublecortin and theprotein kinase domains, which mediates multiple protein-proteininteractions. The microtubule-polymerizing activity of the encodedprotein is independent of its protein kinase activity. The encodedprotein is involved in several different cellular processes,including neuronal migration, retrograde transport, neuronalapoptosis and neurogenesis. This gene is up-regulated bybrain-derived neurotrophic factor and associated with memory andgeneral cognitive abilities. Multiple transcript variants generatedby two alternative promoter usage and alternative splicing havebeen found, but the biological validity of some variants has notbeen determined. These variants encode different isoforms, whichare differentially expressed and have different kinase activities.
Other Names:
Serine/threonine-protein kinase DCLK1, Doublecortin-like and CAM kinase-like 1, Doublecortin-like kinase 1, Dclk1, Dcamkl1, Dclk
Gene Name: Dclk1
Gene ID: 13175
Primary Accession: Q9JLM8
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
This gene encodes a member of the protein kinasesuperfamily and the doublecortin family. The protein encoded bythis gene contains two N-terminal doublecortin domains, which bindmicrotubules and regulate microtubule polymerization, a C-terminalserine/threonine protein kinase domain, which shows substantialhomology to Ca2+/calmodulin-dependent protein kinase, and aserine/proline-rich domain in between the doublecortin and theprotein kinase domains, which mediates multiple protein-proteininteractions. The microtubule-polymerizing activity of the encodedprotein is independent of its protein kinase activity. The encodedprotein is involved in several different cellular processes,including neuronal migration, retrograde transport, neuronalapoptosis and neurogenesis. This gene is up-regulated bybrain-derived neurotrophic factor and associated with memory andgeneral cognitive abilities. Multiple transcript variants generatedby two alternative promoter usage and alternative splicing havebeen found, but the biological validity of some variants has notbeen determined. These variants encode different isoforms, whichare differentially expressed and have different kinase activities.
Other Names:
Serine/threonine-protein kinase DCLK1, Doublecortin-like and CAM kinase-like 1, Doublecortin-like kinase 1, Dclk1, Dcamkl1, Dclk
Gene Name: Dclk1
Gene ID: 13175
Primary Accession: Q9JLM8
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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