Mouse Hes1 Blocking Peptide (C-term)

Background:
Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1 (By similarity). Binds DNA on N-box motifs: 5'-CACNAG-3' with high affinity and on E-box motifs: 5'-CANNTG-3' with low affinity. May play a role in a functional FA core complex response to DNA cross- link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage (By similarity).

Other Names:
Transcription factor HES-1, Hairy and enhancer of split 1, Hes1, Hes-1

Target/Specificity:
The synthetic peptide sequence is selected from aa 205-219 of HUMAN Hes1

Gene Name: Hes1

Gene ID: 15205
Primary Accession: P35428
Other Accession: Q04666; Q14469
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.