Mouse Irf3 Blocking Peptide (N-term)
€363.00
In stock
SKU
AC-BP20073a
Background:
Mediates interferon-stimulated response element (ISRE) promoter activation. Functions as a molecular switch for antiviral activity. DsRNA generated during the course of an viral infection leads to IRF3 phosphorylation on the C-terminal serine/threonine cluster. This induces a conformational change, leading to its dimerization, nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of genes under the control of ISRE. The complex binds to the IE and PRDIII regions on the IFN-alpha and IFN-beta promoters respectively. IRF-3 does not have any transcription activation domains (By similarity).
Other Names:
Interferon regulatory factor 3, IRF-3, Irf3
Target/Specificity:
The synthetic peptide sequence is selected from aa 61-72 of MOUSE Irf3
Gene Name: Irf3
Gene ID: 54131
Primary Accession: P70671
Other Accession: Q764M6; Q4JF28; NP_058545.1
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Mediates interferon-stimulated response element (ISRE) promoter activation. Functions as a molecular switch for antiviral activity. DsRNA generated during the course of an viral infection leads to IRF3 phosphorylation on the C-terminal serine/threonine cluster. This induces a conformational change, leading to its dimerization, nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of genes under the control of ISRE. The complex binds to the IE and PRDIII regions on the IFN-alpha and IFN-beta promoters respectively. IRF-3 does not have any transcription activation domains (By similarity).
Other Names:
Interferon regulatory factor 3, IRF-3, Irf3
Target/Specificity:
The synthetic peptide sequence is selected from aa 61-72 of MOUSE Irf3
Gene Name: Irf3
Gene ID: 54131
Primary Accession: P70671
Other Accession: Q764M6; Q4JF28; NP_058545.1
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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