Mouse Irf3 polyclonal (N-term), anti-mouse
€0.00
In stock
SKU
AC-AP20073a
Catalog Number: AC-AP20073a
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB42372
Applications: WB
Datasheet
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Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB42372
Applications: WB
Datasheet
Request Information
Background:
Mediates interferon-stimulated response element (ISRE) promoter activation. Functions as a molecular switch for antiviral activity. DsRNA generated during the course of an viral infection leads to IRF3 phosphorylation on the C-terminal serine/threonine cluster. This induces a conformational change, leading to its dimerization, nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of genes under the control of ISRE. The complex binds to the IE and PRDIII regions on the IFN-alpha and IFN-beta promoters respectively. IRF-3 does not have any transcription activation domains (By similarity).
Other Names:
Interferon regulatory factor 3, IRF-3, Irf3
Target/Specificity:
This Mouse Irf3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 46-72 amino acids from the N-terminal region of mouse Irf3.
Antigen Region:
46-72
Antigen Type: Synthetic Peptide
Gene Name: Irf3
Gene ID: 54131
Primary Accession: P70671
NCBI Accession: NP_058545.1
Other Accession: Q764M6; Q4JF28; NP_058545.1
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Mediates interferon-stimulated response element (ISRE) promoter activation. Functions as a molecular switch for antiviral activity. DsRNA generated during the course of an viral infection leads to IRF3 phosphorylation on the C-terminal serine/threonine cluster. This induces a conformational change, leading to its dimerization, nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of genes under the control of ISRE. The complex binds to the IE and PRDIII regions on the IFN-alpha and IFN-beta promoters respectively. IRF-3 does not have any transcription activation domains (By similarity).
Other Names:
Interferon regulatory factor 3, IRF-3, Irf3
Target/Specificity:
This Mouse Irf3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 46-72 amino acids from the N-terminal region of mouse Irf3.
Antigen Region:
46-72
Antigen Type: Synthetic Peptide
Gene Name: Irf3
Gene ID: 54131
Primary Accession: P70671
NCBI Accession: NP_058545.1
Other Accession: Q764M6; Q4JF28; NP_058545.1
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
| Is Featured? | No |
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