Mouse Kdm6a Blocking Peptide (C-term)

Background:
Histone demethylase that specifically demethylates 'Lys- 27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Demethylation of 'Lys-27' of histone H3 is concomitant with methylation of 'Lys-4' of histone H3, and regulates the recruitment of the PRC1 complex and monoubiquitination of histone H2A (By similarity).

Other Names:
Lysine-specific demethylase 6A, 11411-, Histone demethylase UTX, Ubiquitously transcribed TPR protein on the X chromosome, Ubiquitously transcribed X chromosome tetratricopeptide repeat protein, Kdm6a, Utx

Target/Specificity:
The synthetic peptide sequence is selected from aa 1041-1054 of HUMAN Kdm6a

Gene Name: Kdm6a

Gene ID: 22289
Primary Accession: O70546
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.