Mouse p21Cip1 polyclonal (C-term S148), anti-mouse
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In stock
SKU
AC-AP20419b
Catalog Number: AC-AP20419b
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB43031
Applications: WB
Datasheet
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Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB43031
Applications: WB
Datasheet
Request Information
Background:
May be the important intermediate by which p53/TP53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex (By similarity).
Other Names:
Cyclin-dependent kinase inhibitor 1, CDK-interacting protein 1, Melanoma differentiation-associated protein, p21, Cdkn1a, Cip1, Waf1
Target/Specificity:
This Mouse p21Cip1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 126-154 amino acids from the C-terminal region of mouse p21Cip1.
Antigen Region:
126-154
Antigen Type: Synthetic Peptide
Gene Name: Cdkn1a
Gene ID: 12575
Primary Accession: P39689
NCBI Accession: NP_001104569.1;NP_031695.1
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
May be the important intermediate by which p53/TP53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex (By similarity).
Other Names:
Cyclin-dependent kinase inhibitor 1, CDK-interacting protein 1, Melanoma differentiation-associated protein, p21, Cdkn1a, Cip1, Waf1
Target/Specificity:
This Mouse p21Cip1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 126-154 amino acids from the C-terminal region of mouse p21Cip1.
Antigen Region:
126-154
Antigen Type: Synthetic Peptide
Gene Name: Cdkn1a
Gene ID: 12575
Primary Accession: P39689
NCBI Accession: NP_001104569.1;NP_031695.1
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
| Is Featured? | No |
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