Mouse Pim1 polyclonal (C-term), anti-human, mouse
€0.00
In stock
SKU
AC-AP14077B
Catalog Number: AC-AP14077B
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB34666
Applications: WB
Datasheet
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Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB34666
Applications: WB
Datasheet
Request Information
Background:
Pim1 may affect the structure or silencing of chromatin by phosphorylating HP1 gamma/CBX3 (By similarity). Promotes the G1/S transition of the cell cycle via up-regulation of CDK2 activity and phosphorylation of CDKN1B, resulting in enhanced nuclear export and proteasome-dependent degradation of CDKN1B (By similarity). Also represses CDKN1B transcription by phosphorylating and inactivating the transcription factor FOXO3 (By similarity). Plays a role in signal transduction in blood cells (By similarity). Contributes to both cell proliferation and survival thus providing a selective advantage in tumorigenesis (By similarity).
Other Names:
Serine/threonine-protein kinase pim-1, Pim1, Pim-1
Target/Specificity:
This Mouse Pim1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 343-372 amino acids from the C-terminal region of mouse Pim1.
Antigen Region:
343-372
Antigen Type: Synthetic Peptide
Gene Name: Pim1
Gene ID: 18712
Primary Accession: P06803
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Pim1 may affect the structure or silencing of chromatin by phosphorylating HP1 gamma/CBX3 (By similarity). Promotes the G1/S transition of the cell cycle via up-regulation of CDK2 activity and phosphorylation of CDKN1B, resulting in enhanced nuclear export and proteasome-dependent degradation of CDKN1B (By similarity). Also represses CDKN1B transcription by phosphorylating and inactivating the transcription factor FOXO3 (By similarity). Plays a role in signal transduction in blood cells (By similarity). Contributes to both cell proliferation and survival thus providing a selective advantage in tumorigenesis (By similarity).
Other Names:
Serine/threonine-protein kinase pim-1, Pim1, Pim-1
Target/Specificity:
This Mouse Pim1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 343-372 amino acids from the C-terminal region of mouse Pim1.
Antigen Region:
343-372
Antigen Type: Synthetic Peptide
Gene Name: Pim1
Gene ID: 18712
Primary Accession: P06803
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
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