Mouse Rad50 polyclonal (C-term), anti-mouse
€0.00
In stock
SKU
AC-AP19224b
Catalog Number: AC-AP19224b
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB40014
Applications: WB
Datasheet
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Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB40014
Applications: WB
Datasheet
Request Information
Background:
Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11A to prevent nucleolytic degradation past a given point. The complex may also be required for DNA damage signaling via activation of the ATM kinase. In telomeres the MRN complex may modulate t-loop formation (By similarity).
Other Names:
DNA repair protein RAD50, mRad50, 36--, Rad50
Target/Specificity:
This Mouse Rad50 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 911-938 amino acids from the C-terminal region of mouse Rad50.
Antigen Region:
911-938
Antigen Type: Synthetic Peptide
Gene Name: Rad50
Primary Accession: P70388
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11A to prevent nucleolytic degradation past a given point. The complex may also be required for DNA damage signaling via activation of the ATM kinase. In telomeres the MRN complex may modulate t-loop formation (By similarity).
Other Names:
DNA repair protein RAD50, mRad50, 36--, Rad50
Target/Specificity:
This Mouse Rad50 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 911-938 amino acids from the C-terminal region of mouse Rad50.
Antigen Region:
911-938
Antigen Type: Synthetic Peptide
Gene Name: Rad50
Primary Accession: P70388
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
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