Mouse Rnasel polyclonal (N-term), anti-mouse
€0.00
In stock
SKU
AC-AP17440a
Catalog Number: AC-AP17440a
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB37131
Applications: WB
Datasheet
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Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB37131
Applications: WB
Datasheet
Request Information
Background:
Endoribonuclease that functions in the interferon (IFN) antiviral response. In INF treated and virus infected cells, RNASEL probably mediates its antiviral effects through a combination of direct cleavage of single-stranded viral RNAs, inhibition of protein synthesis through the degradation of rRNA, induction of apoptosis, and induction of other antiviral genes. RNASEL mediated apoptosis is the result of a JNK-dependent stress-response pathway leading to cytochrome c release from mitochondria and caspase-dependent apoptosis. Therefore, activation of RNASEL could lead to elimination of virus infected cells under some circumstances. Might play a central role in the regulation of mRNA turnover (By similarity).
Other Names:
2-5A-dependent ribonuclease, 2-5A-dependent RNase, 3126-, Ribonuclease 4, Ribonuclease L, RNase L, Rnasel, Rns4
Target/Specificity:
This Mouse Rnasel antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 140-167 amino acids from the N-terminal region of mouse Rnasel.
Antigen Region:
140-167
Antigen Type: Synthetic Peptide
Gene Name: Rnasel
Gene ID: 24014
Primary Accession: Q05921
NCBI Accession: NP_036012.1
Other Accession: NP_036012.1
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Endoribonuclease that functions in the interferon (IFN) antiviral response. In INF treated and virus infected cells, RNASEL probably mediates its antiviral effects through a combination of direct cleavage of single-stranded viral RNAs, inhibition of protein synthesis through the degradation of rRNA, induction of apoptosis, and induction of other antiviral genes. RNASEL mediated apoptosis is the result of a JNK-dependent stress-response pathway leading to cytochrome c release from mitochondria and caspase-dependent apoptosis. Therefore, activation of RNASEL could lead to elimination of virus infected cells under some circumstances. Might play a central role in the regulation of mRNA turnover (By similarity).
Other Names:
2-5A-dependent ribonuclease, 2-5A-dependent RNase, 3126-, Ribonuclease 4, Ribonuclease L, RNase L, Rnasel, Rns4
Target/Specificity:
This Mouse Rnasel antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 140-167 amino acids from the N-terminal region of mouse Rnasel.
Antigen Region:
140-167
Antigen Type: Synthetic Peptide
Gene Name: Rnasel
Gene ID: 24014
Primary Accession: Q05921
NCBI Accession: NP_036012.1
Other Accession: NP_036012.1
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
| Is Featured? | No |
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