Mouse Tbk1 polyclonal (N-term), anti-mouse
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In stock
SKU
AC-AP17321a
Catalog Number: AC-AP17321a
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB37152
Applications: WB
Datasheet
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Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB37152
Applications: WB
Datasheet
Request Information
Background:
Serine/threonine protein involved in the signaling cascade converging to the activation of the transcription factor NF-kappa-B. May function as an IKK kinase, playing an essential role in the transcription of a subset of a TNF-alpha-induced genes. Also mediates production of RANTES/CCL5 and interferon-beta/IFNB1. Has a pivotal role in the innate immune response. Phosphorylates and activates IRF3 and IRF7 and allows their nuclear localization. This leads to production of alpha/beta interferons and the development of a cellular antiviral state. It also seems to be a central factor in the induction of the antiviral interferon response.
Other Names:
Serine/threonine-protein kinase TBK1, T2K, TANK-binding kinase 1, Tbk1
Target/Specificity:
This Mouse Tbk1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 8-35 amino acids from the N-terminal region of mouse Tbk1.
Antigen Region:
8-35
Antigen Type: Synthetic Peptide
Gene Name: Tbk1 {ECO:0000303|PubMed:10581243, ECO:0000312|MGI:MGI:1929658}
Gene ID: 56480
Primary Accession: Q9WUN2
NCBI Accession: NP_062760.3
Other Accession: NP_062760.3
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Serine/threonine protein involved in the signaling cascade converging to the activation of the transcription factor NF-kappa-B. May function as an IKK kinase, playing an essential role in the transcription of a subset of a TNF-alpha-induced genes. Also mediates production of RANTES/CCL5 and interferon-beta/IFNB1. Has a pivotal role in the innate immune response. Phosphorylates and activates IRF3 and IRF7 and allows their nuclear localization. This leads to production of alpha/beta interferons and the development of a cellular antiviral state. It also seems to be a central factor in the induction of the antiviral interferon response.
Other Names:
Serine/threonine-protein kinase TBK1, T2K, TANK-binding kinase 1, Tbk1
Target/Specificity:
This Mouse Tbk1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 8-35 amino acids from the N-terminal region of mouse Tbk1.
Antigen Region:
8-35
Antigen Type: Synthetic Peptide
Gene Name: Tbk1 {ECO:0000303|PubMed:10581243, ECO:0000312|MGI:MGI:1929658}
Gene ID: 56480
Primary Accession: Q9WUN2
NCBI Accession: NP_062760.3
Other Accession: NP_062760.3
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
| Is Featured? | No |
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