Mouse TLR1 polyclonal (C-term), anti-mouse
€0.00
In stock
SKU
AC-AP1501b
Catalog Number: AC-AP1501b
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB2599
Applications: IHC-P, WB
Datasheet
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Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB2599
Applications: IHC-P, WB
Datasheet
Request Information
Background:
Higher animals establish host defense by orchestrating innate and adaptive immunity. This is mediated by professional antigen presenting cells, i.e. dendritic cells (DCs). DCs can incorporate pathogens, produce a variety of cytokines, maturate, and present pathogen-derived peptides to T cells, thereby inducing T cell activation and differentiation. These responses are triggered by microbial recognition through type I transmembrane proteins, Toll-like receptors (TLRs) on DCs. TLRs consist of ten members and each TLR is involved in recognizing a variety of microorganism-derived molecular structures. TLR ligands include cell wall components, proteins, nucleic acids, and synthetic chemical compounds, all of which can activate DCs as immune adjuvants. Each TLR can activate DCs in a similar, but distinct manner. For example, TLRs can be divided into subgroups according to their type I interferon (IFN) inducing ability. TLR2 cannot induce IFN-alpha or IFN-beta, but TLR4 can lead to IFN-beta production. Meanwhile, TLR3, TLR7, and TLR9 can induce both IFN-alpha and IFN-beta. Recent evidences suggest that cytoplamic adapters for TLRs are especially crucial for this functional heterogeneity.
Other Names:
Toll-like receptor 1, Toll/interleukin-1 receptor-like protein, TIL, CD281, Tlr1
Target/Specificity:
This Mouse TLR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 764-795 amino acids from the C-terminal region of mouse TLR1.
Antigen Region:
764-795
Antigen Type: Synthetic Peptide
Gene Name: Tlr1
Gene ID: 21897
Primary Accession: Q9EPQ1
NCBI Accession: NP_001263374.1;NP_109607.1
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Higher animals establish host defense by orchestrating innate and adaptive immunity. This is mediated by professional antigen presenting cells, i.e. dendritic cells (DCs). DCs can incorporate pathogens, produce a variety of cytokines, maturate, and present pathogen-derived peptides to T cells, thereby inducing T cell activation and differentiation. These responses are triggered by microbial recognition through type I transmembrane proteins, Toll-like receptors (TLRs) on DCs. TLRs consist of ten members and each TLR is involved in recognizing a variety of microorganism-derived molecular structures. TLR ligands include cell wall components, proteins, nucleic acids, and synthetic chemical compounds, all of which can activate DCs as immune adjuvants. Each TLR can activate DCs in a similar, but distinct manner. For example, TLRs can be divided into subgroups according to their type I interferon (IFN) inducing ability. TLR2 cannot induce IFN-alpha or IFN-beta, but TLR4 can lead to IFN-beta production. Meanwhile, TLR3, TLR7, and TLR9 can induce both IFN-alpha and IFN-beta. Recent evidences suggest that cytoplamic adapters for TLRs are especially crucial for this functional heterogeneity.
Other Names:
Toll-like receptor 1, Toll/interleukin-1 receptor-like protein, TIL, CD281, Tlr1
Target/Specificity:
This Mouse TLR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 764-795 amino acids from the C-terminal region of mouse TLR1.
Antigen Region:
764-795
Antigen Type: Synthetic Peptide
Gene Name: Tlr1
Gene ID: 21897
Primary Accession: Q9EPQ1
NCBI Accession: NP_001263374.1;NP_109607.1
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
| Is Featured? | No |
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