Mouse TLR3 polyclonal (N-term), anti-mouse
€0.00
In stock
SKU
AC-AP1503c
Catalog Number: AC-AP1503c
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB2606
Applications: IHC-P
Datasheet
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Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB2606
Applications: IHC-P
Datasheet
Request Information
Background:
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection, and induces the activation of NF-kappaB and the production of type I interferons. It may thus play a role in host defense against viruses. Use of alternative polyadenylation sites to generate different length transcripts has been noted for this gene.
Other Names:
Toll-like receptor 3, CD283, Tlr3
Target/Specificity:
This Mouse TLR3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 31~60 amino acids from the N-terminal region of mouse TLR3.
Antigen Region:
31-60
Antigen Type: Synthetic Peptide
Gene Name: Tlr3 {ECO:0000312|MGI:MGI:2156367}
Gene ID: 142980
Primary Accession: Q99MB1
NCBI Accession: NP_569054.2
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection, and induces the activation of NF-kappaB and the production of type I interferons. It may thus play a role in host defense against viruses. Use of alternative polyadenylation sites to generate different length transcripts has been noted for this gene.
Other Names:
Toll-like receptor 3, CD283, Tlr3
Target/Specificity:
This Mouse TLR3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 31~60 amino acids from the N-terminal region of mouse TLR3.
Antigen Region:
31-60
Antigen Type: Synthetic Peptide
Gene Name: Tlr3 {ECO:0000312|MGI:MGI:2156367}
Gene ID: 142980
Primary Accession: Q99MB1
NCBI Accession: NP_569054.2
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
| Is Featured? | No |
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