Mouse Wee1 polyclonal (Center), anti-human
€0.00
In stock
SKU
AC-AP19012C
Catalog Number: AC-AP19012C
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB39511
Applications: WB
Datasheet
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Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB39511
Applications: WB
Datasheet
Request Information
Background:
Wee1 may act as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-complexed CDK1 before the onset of mitosis. Its activity increases during S and G2 phases and decreases at M phase when it is hyperphosphorylated. A correlated decrease in protein level occurs at M/G1 phase, probably due to its degradation. Specifically phosphorylates and inactivates cyclin B1-complexed CDK1 reaching a maximum during G2 phase and a minimum as cells enter M phase. Phosphorylation of cyclin B1-CDK1 occurs exclusively on 'Tyr-15' and phosphorylation of monomeric CDK1 does not occur (By similarity).
Other Names:
Wee1-like protein kinase, Wee1A kinase, Wee1
Target/Specificity:
This Mouse Wee1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 202-230 amino acids from the Central region of mouse Wee1.
Antigen Region:
202-230
Antigen Type: Synthetic Peptide
Gene Name: Wee1
Gene ID: 22390
Primary Accession: P47810
NCBI Accession: NP_033542.2
Other Accession: Q63802; NP_033542.2
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Wee1 may act as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-complexed CDK1 before the onset of mitosis. Its activity increases during S and G2 phases and decreases at M phase when it is hyperphosphorylated. A correlated decrease in protein level occurs at M/G1 phase, probably due to its degradation. Specifically phosphorylates and inactivates cyclin B1-complexed CDK1 reaching a maximum during G2 phase and a minimum as cells enter M phase. Phosphorylation of cyclin B1-CDK1 occurs exclusively on 'Tyr-15' and phosphorylation of monomeric CDK1 does not occur (By similarity).
Other Names:
Wee1-like protein kinase, Wee1A kinase, Wee1
Target/Specificity:
This Mouse Wee1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 202-230 amino acids from the Central region of mouse Wee1.
Antigen Region:
202-230
Antigen Type: Synthetic Peptide
Gene Name: Wee1
Gene ID: 22390
Primary Accession: P47810
NCBI Accession: NP_033542.2
Other Accession: Q63802; NP_033542.2
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
| Is Featured? | No |
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