Mre11 Antibody (Center K475) Blocking Peptide
€363.00
In stock
SKU
AC-BP6656c
Background:
MRE11 is a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments.
Other Names:
Double-strand break repair protein MRE11A, Meiotic recombination 11 homolog 1, MRE11 homolog 1, Meiotic recombination 11 homolog A, MRE11 homolog A, MRE11A, HNGS1, MRE11
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP6656c was selected from the Center region of human Mre11. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: MRE11 {ECO:0000303|PubMed:8530104, ECO:0000312|HGNC:HGNC:7230}
Gene ID: 4361
Primary Accession: P49959
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
MRE11 is a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments.
Other Names:
Double-strand break repair protein MRE11A, Meiotic recombination 11 homolog 1, MRE11 homolog 1, Meiotic recombination 11 homolog A, MRE11 homolog A, MRE11A, HNGS1, MRE11
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP6656c was selected from the Center region of human Mre11. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: MRE11 {ECO:0000303|PubMed:8530104, ECO:0000312|HGNC:HGNC:7230}
Gene ID: 4361
Primary Accession: P49959
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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