MRP1 polyclonal, anti-human, mouse, rat

Quantity: 100 µg

Background:
ABCC1(ATP-BINDING CASSETTE, SUBFAMILY C, MEMBER 1), also called MRP1 or MRP, is a protein that in humans is encoded by the ABCC1 gene. The ABCC1 is a member of the superfamily of ATP-binding cassette(ABC) transporters. The ABCC1 is a plasma membrane drug-efflux pump.The ABCC1 gene is mapped to chromosome 16p13.1 by isotopic in situ hybridization. ABCC1 functions as a multispecific organic anion transporter, with oxidized glutathione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates and it also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Blocking ABCC1 efflux pumps increases the susceptibility of the cells to the toxic effects of unconjugated bilirubin, suggesting that ABCC1 is an important protector in this scenario. ABCC1 clears beta-amyloid from brains of mice and can be activated by thiethylperazine. And Chemotaxis assays show that ABCC1-mediated transport of S1P influenced mast-cell migration, but not mast-cell degranulation.

Description:
Rabbit IgG polyclonal antibody for Multidrug resistance-associated protein 1 (ABCC1) detection. Tested with WB, IHC-P in Human, Mouse, Rat.

Synonyms:
ABC 29 antibody, ABC29 antibody, ABCC 1 antibody, ABCC antibody, ABCC1 antibody, ATP binding cassette sub family C(CFTR/MRP) member 1 antibody, ATP binding cassette sub-family C member 1 antibody, ATP-binding cassette sub-family C member 1 antibody, DKFZp686N04233 antibody, DKFZp781G125 antibody, GS X antibody, GSX antibody, Leukotriene C(4) transporter antibody, LTC4 transporter antibody, MRP 1 antibody, MRP antibody, MRP1_HUMAN antibody, Multidrug resistance associated protein 1 antibody, Multidrug resistance protein antibody, Multidrug resistance-associated protein 1 antibody, Multiple drug resistance associated protein antibody, Multiple drug resistance protein 1 antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence at the C-terminus of human MRP1(1514-1531aa, LLQQRGLFYSMAKDAGLV), different from the related rat and mouse sequences by one amino acid.A synthetic peptide corresponding to a sequence at the C-terminus of human MRP1(1514-1531aa, LLQQRGLFYSMAKDAGLV), different from the related rat and mouse sequences by one amino acid.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human, rat.
Predicted to work with: mouse.

Applications: WB, IHC-P

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.