MRP2 Polyclonal Antibody

Background:
ATP binding cassette subfamily C member 2(ABCC2) Homo sapiens The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine; therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia. [provided by RefSeq, Jul 2008],

Alternative Names:
ABCC2, CMOAT, CMOAT1, CMRP, MRP2, Canalicular multispecific organic anion transporter 1, ATP-binding cassette sub-family C member 2, Canalicular multidrug resistance protein, Multidrug resistance-asso

Immunogen: The antiserum was produced against synthesized peptide derived from human ABCC2. AA range:991-1040

Isotype: Rabbit

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration: 1 mg/ml

Observed band: 175

GeneID: ABCC2

Storage: -20°C/1 year

NOTE: For Research Use Only