MRP4 polyclonal, anti-human, mouse, rat

Quantity: 100 µg

Background:
ABCC4(Atp-binding cassette, subfamily c, member 4) also known as MRP4 or MOATB, is a protein that in humans is encoded by the ABCC4 gene. The ABCC4 belongs to a large family of transmembrane proteins involved in active transport of substrates out of cells. By radiation hybrid analysis, Kool et al.(1997) mapped the ABCC4 gene to chromosome 13. Using FISH, Lee et al.(1998) refined the localization to chromosome 13q32. ABCC4 acts as an independent regulator of intracellular cyclic nucleotide levels and as a mediator of cAMP-dependent signal transduction to the nucleus. The antiproliferative effect of MRP4 inhibition was related to cAMP-dependent PKA activation and CREB phosphorylation. Pharmacologic inhibition of MRP4 activity or knockdown of MRP4 via RNA interference resulted in reduced migration of DCs from human skin explants and of in vitro-generated Langerhans cells. Van de Ven et al.(2008) concluded that MRP4 contributes to migration of DCs toward draining lymph nodes and therefore has a role in the initiation of an immune response.

Description:
Rabbit IgG polyclonal antibody for Multidrug resistance-associated protein 4 (ABCC4) detection. Tested with WB in Human, Mouse, Rat.

Synonyms:
ABCC 4 antibody, ABCC4 antibody, ATP binding cassette sub family C(CFTR/MRP) member 4 antibody, ATP binding cassette sub family C member 4 antibody, ATP binding cassette subfamily C member 4 antibody, ATP-binding cassette sub-family C member 4 antibody, bA464I2.1(ATP binding cassette, sub-family C(CFTR/MRP) member 4) antibody, bA464I2.1 antibody, Canalicular multispecific organic anion transporter ABC superfamily antibody, canalicular multispecific organic anion transporter antibody, EST170205 antibody, MOAT B antibody, MOAT-B antibody, MOATB antibody, MRP 4 antibody, MRP cMOAT related ABC transporter antibody, MRP/cMOAT related ABC transporter antibody, MRP/cMOAT-related ABC transporter antibody, MRP4_HUMAN antibody, Multi specific organic anion transporter B antibody, Multi-specific organic anion transporter B antibody, Multidrug resistance associated protein 4 antibody, Multidrug resistance-associated protein 4 antibody, Multispecific organic anion tranporter B antibody, OTTHUMP00000018560 antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence at the N-terminus of human MRP4(26-43aa WLNPLFKIGHKRRLEEDD), different from the related rat and mouse sequences by one amino acid.A synthetic peptide corresponding to a sequence at the N-terminus of human MRP4(26-43aa WLNPLFKIGHKRRLEEDD), different from the related rat and mouse sequences by one amino acid.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human.
Predicted to work with: mouse, rat.

Applications: WB

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.