MRP4 polyclonal, anti-human, mouse, rat

Quantity: 100 µg

Background:
ABCC4(Atp-binding cassette, subfamily c, member 4) also known as MRP4 or MOATB, is a protein that in humans is encoded by the ABCC4 gene. It belongs to a large family of transmembrane proteins involved in active transport of substrates out of cells. This gene is mapped to chromosome 13q32. ABCC4 acts as an independent regulator of intracellular cyclic nucleotide levels and as a mediator of cAMP-dependent signal transduction to the nucleus. The antiproliferative effect of ABCC4 inhibition was related to cAMP-dependent PKA activation and CREB phosphorylation. Pharmacologic inhibition of ABCC4 activity or knockdown of ABCC4 via RNA interference resulted in reduced migration of DCs from human skin explants and of in vitro-generated Langerhans cells. It has been found that ABCC4 contributes to migration of DCs toward draining lymph nodes and therefore has a role in the initiation of an immune response.

Description:
Rabbit IgG polyclonal antibody for Multidrug resistance-associated protein 4 (ABCC4) detection. Tested with WB, IHC-P in Human, Mouse, Rat.

Synonyms:
ABCC 4 antibody, ABCC4 antibody, ATP binding cassette sub family C (CFTR/MRP) member 4 antibody, ATP binding cassette sub family C member 4 antibody, ATP-binding cassette sub-family C member 4 antibody, bA464I2.1 (ATP binding cassette, sub-family C (CFTR/MRP) member 4) antibody, bA464I2.1 antibody, Canalicular multispecific organic anion transporter ABC superfamily antibody, canalicular multispecific organic anion transporter antibodyEST170205 antibody, MOAT B antibody, MOAT-B antibody, MOATB antibody, MRP 4 antibody, MRP/cMOAT related ABC transporter antibody, MRP/cMOAT-related ABC transporter antibody, MRP4_HUMAN antibody, Multi specific organic anion transporter B antibody, Multi-specific organic anion transporter B antibody, Multidrug resistance associated protein 4 antibody, Multidrug resistance-associated protein 4 antibody, OTTHUMP00000018560 antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
E.coli-derived human MRP4 recombinant protein (Position: M1-P370).

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human, mouse, rat

Applications: WB, IHC-P

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.