MRVI1 Antibody (N-term) Blocking peptide
€363.00
In stock
SKU
AC-BP13441a
Background:
This gene is similar to a putative mouse tumor suppressorgene (Mrvi1) that is frequently disrupted by mouse AIDS-relatedvirus (MRV). The encoded protein, which is found in the membrane ofthe endoplasmic reticulum, is similar to Jaw1, alymphoid-restricted protein whose expression is downregulatedduring lymphoid differentiation. Studies in mouse suggest that MRVintegration at Mrvi1 induces myeloid leukemia by altering theexpression of a gene important for myeloid cell growth and/ordifferentiation, and thus this gene may function as a myeloidleukemia tumor suppressor gene. Several alternatively splicedtranscript variants encoding different isoforms have been found forthis gene, few of which initiate translation at a non-AUG (CUG)start site.
Other Names:
Protein MRVI1, Inositol 1,5-trisphosphate receptor-associated cGMP kinase substrate, JAW1-related protein MRVI1, MRVI1, IRAG, JAW1L
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP13441a was selected from the N-term region of MRVI1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: IRAG1 (HGNC:7237)
Gene ID: 10335
Primary Accession: Q9Y6F6
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
This gene is similar to a putative mouse tumor suppressorgene (Mrvi1) that is frequently disrupted by mouse AIDS-relatedvirus (MRV). The encoded protein, which is found in the membrane ofthe endoplasmic reticulum, is similar to Jaw1, alymphoid-restricted protein whose expression is downregulatedduring lymphoid differentiation. Studies in mouse suggest that MRVintegration at Mrvi1 induces myeloid leukemia by altering theexpression of a gene important for myeloid cell growth and/ordifferentiation, and thus this gene may function as a myeloidleukemia tumor suppressor gene. Several alternatively splicedtranscript variants encoding different isoforms have been found forthis gene, few of which initiate translation at a non-AUG (CUG)start site.
Other Names:
Protein MRVI1, Inositol 1,5-trisphosphate receptor-associated cGMP kinase substrate, JAW1-related protein MRVI1, MRVI1, IRAG, JAW1L
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP13441a was selected from the N-term region of MRVI1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: IRAG1 (HGNC:7237)
Gene ID: 10335
Primary Accession: Q9Y6F6
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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