MSH2 polyclonal, anti-human
€305.00
In stock
SKU
BS61570
Background:
The DNA mismatch repair system (MMR) repairs post-replication DNA, inhibits recombination between non-identical DNA sequences and induces both checkpoint and apoptotic responses following certain types of DNA damage. MSH2 (MutS homologue 2) forms the hMutS-α dimer with MSH6 and is an essential component of the mismatch repair process. hMutS-α is part of the BRCA1-associated surveillance complex (BASC), a complex that also contains BRCA1, MLH1, ATM, BLM, PMS2 proteins and the Rad50-Mre11-NBS1 complex.
Alternative Name:
DNA mismatch repair protein Msh2, hMSH2, MutS protein homolog 2
Application Dilution: WB: 1:500~1:1000
Specificity: MSH2 polyclonal antibody detects endogenous levels of MSH2 protein.
Immunogen:
Synthetic peptide, corresponding to amino acids 545-589 of Human MSH2
MW: ~ 100 kDa
Swis Prot.: P43246
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE)
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.3.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
The DNA mismatch repair system (MMR) repairs post-replication DNA, inhibits recombination between non-identical DNA sequences and induces both checkpoint and apoptotic responses following certain types of DNA damage. MSH2 (MutS homologue 2) forms the hMutS-α dimer with MSH6 and is an essential component of the mismatch repair process. hMutS-α is part of the BRCA1-associated surveillance complex (BASC), a complex that also contains BRCA1, MLH1, ATM, BLM, PMS2 proteins and the Rad50-Mre11-NBS1 complex.
Alternative Name:
DNA mismatch repair protein Msh2, hMSH2, MutS protein homolog 2
Application Dilution: WB: 1:500~1:1000
Specificity: MSH2 polyclonal antibody detects endogenous levels of MSH2 protein.
Immunogen:
Synthetic peptide, corresponding to amino acids 545-589 of Human MSH2
MW: ~ 100 kDa
Swis Prot.: P43246
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE)
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.3.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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