MSH2 polyclonal, anti-human, mouse, rat
€388.00
In stock
SKU
BS6056
Background:
Component of the post-replicative DNA mismatch repair system (MMR). Forms two different heterodimers: MutS alpha (MSH2-MSH6 heterodimer) and MutS beta (MSH2-MSH3 heterodimer) which binds to DNA mismatches thereby initiating DNA repair. When bound, heterodimers bend the DNA helix and shields approximately 20 base pairs. MutS alpha recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. MutS beta recognizes larger insertion-deletion loops up to 13 nucleotides long.
Alternative Name:
DNA mismatch repair protein Msh2, hMSH2, MutS protein homolog 2, MSH2
Application Dilution: WB: 1:500 - 1:2000, IP: 1:20 - 1:50
Specificity: MSH2 polyclonal antibody detects endogenous levels of MSH2 protein.
Immunogen:
Recombinant full length Human MSH2.
MW: ~ 105 kDa
Swis Prot.: P43246
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Component of the post-replicative DNA mismatch repair system (MMR). Forms two different heterodimers: MutS alpha (MSH2-MSH6 heterodimer) and MutS beta (MSH2-MSH3 heterodimer) which binds to DNA mismatches thereby initiating DNA repair. When bound, heterodimers bend the DNA helix and shields approximately 20 base pairs. MutS alpha recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. MutS beta recognizes larger insertion-deletion loops up to 13 nucleotides long.
Alternative Name:
DNA mismatch repair protein Msh2, hMSH2, MutS protein homolog 2, MSH2
Application Dilution: WB: 1:500 - 1:2000, IP: 1:20 - 1:50
Specificity: MSH2 polyclonal antibody detects endogenous levels of MSH2 protein.
Immunogen:
Recombinant full length Human MSH2.
MW: ~ 105 kDa
Swis Prot.: P43246
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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