Msh2 polyclonal, anti-human, mouse, rat, pig

Protein Family: Enzymes

Pathway and Disease: Cancers, Replication and Repair

Description:
DNA mismatch repair protein Msh2 (Msh2) is a component of the post-replicative DNA mismatch repair system (MMR). Msh2 forms two different heterodimers: MutS alpha (MSH2-MSH6 heterodimer) and MutS beta (MSH2-MSH3 heterodimer) which binds to DNA mismatches thereby initiating DNA repair. When bound, heterodimers bend the DNA helix and shield approximately 20 base pairs. MutS alpha recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA.

Alternate Names: MSH2, DNA mismatch repair protein Msh2, MutS protein homolog 2

Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500; IP: 1:100-1:500

Accession No.: P43246

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human Msh2.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.