MSH2 Polyclonal Antibody

Background:
This locus is frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). When cloned, it was discovered to be a human homolog of the E. coli mismatch repair gene mutS, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in HNPCC. Two transcript variants encoding different isoforms have been found for this gene.

Research Area: Cancer, Epigenetics and Nuclear Signaling

Synonyms:
MSH2, COCA1, FCC1, HNPCC, HNPCC1, LCFS2

Immunogen: Recombinant fusion protein of human MSH2 (NP_000242.1).

Swissprot: P43246
Gene ID: 4436

Calculated MW: 97 kDa/104 kDa
Observed MW: 105 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: "WB 1:500-1:2000"

Storage:
Store at -20°C. Avoid freeze / thaw cycles.